We have been and are involved in characterizing and functionalizing nanobubbles and nanodrops for biomedical applications with a focus on CNS applications. Nanobubbles can bring oxygen to hypoxic tissues, be visualized by US (or MRI if decorated with superparamagnetic nanoscale particles), be guided on a target through biochemical or magnetic mechanisms, become mimetic,
transport and release in an intelligent way active compounds for therapy (e.g. drugs, curcumin, mRNA fragments, oxygen...) through the interaction with US or EM fields
Physical driving and magnetic properties (Cavalli)
Biological effects on cultures and delivery of antimicrobial and chemotherapeutic drugs (Cavalli, Prato, Khadjavi, Magnetto)
'Green' Nanotool for Food Preservation (Guiot, Ficiarà, Stura, Zunaira, Cavallo, Banche, Cavalli)
Biological implications and delivery of active ingredients/drugs (Cavalli, 2012-2019) Nanostruttures for gas and/or active ingredient delivery and their uses (patent 2013, 2015) Acoustic Vaporization of Polymer-Lipid Coated Droplets (Ph.D. Thesis, Zullino)
Nanobubbles as ultrasound contrast agents (Cavalli, Zullino, Università di Rotterdam)
Modulation of placental and tumor hypoxia by oxygenated nanobubbles: proposal of a multidisciplinary therapeutic approach (Progetto ORTO11CE8R, €228.054; Fondo ricerca Ateneo-San Paolo 2011 )
Oxygen delivery (Cavalli, 2005-2011)
University funding (2002-2009)
Piedmont Region funding (2008)
Veiculation by ultrasound of O2 encapsulated in nanobubbles in hypoxic tissues: experimental model and identification of clinical context (PRIN responsible 2006-2008, scientific coordinator Alippi)
Thermosensitive chitosan-based microbubbles for diagnostic and therapeutic use and for non-invasive monitoring of tissue temperature (Cavalli, Guiot, Trotta, brevetto 2005)
Nanobubbles based on chitosan for the delivery of oxygen and active ingredients in tissues (Cavalli, Guiot, Trotta, brevetto 2005)